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Article

Impaired AIS plasticity in ankyrin-G mutant mice alters cortical excitability and behavior.

Proceedings of the National Academy of Sciences of the United States of America - 2 Dec 2025

Li Min, Zhao Bingqing, Lu Zhimin, Zhe Liu, Han Yue, Chen Yating, Wang Huichao, Wang Yu, Wu Chunsheng, Zhang Mingjie, Chen Keyu, Yang Rui

Abstract excerpt

The developing brain undergoes neuroplasticity driven by learning, experience, and memory formation. The axon initial segment (AIS) is a specialized membrane domain within the proximal axon that initiates action potential. Studies have demonstrated that the AIS exhibits plasticity by altering its length and/or localization to adjust the excitability in response to neural stimuli. However, how AIS plasticity may...

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Identifiers

PMID: 41284870
DOI: 10.1073/pnas.2513363122
PMCID: PMC12685073

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