Article
Mouse Cntnap2 and Human CNTNAP2 ASD Alleles Cell Autonomously Regulate PV+ Cortical Interneurons.
Cerebral cortex (New York, N.Y. : 1991) - 1 Nov 2018
Vogt Daniel, Cho Kathleen K A, Shelton Samantha M, Paul Anirban, Huang Z Josh, Sohal Vikaas S, Rubenstein John L R
Abstract excerpt
Human mutations in CNTNAP2 are associated with an array of neuropsychiatric and neurological syndromes, including speech and language disorders, epilepsy, and autism spectrum disorder (ASD). We examined Cntnap2's expression and function in GABAergic cortical interneurons (CINs), where its RNA is present at highest levels in chandelier neurons, PV+ neurons and VIP+ neurons. In vivo functions were studied using...
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