Programs, Origins, and Niches of Immunomodulatory Myeloid Cells in Gliomas

Abstract excerpt

<h4>ABSTRACT</h4> Gliomas are incurable malignancies notable for an immunosuppressive microenvironment with abundant myeloid cells whose immunomodulatory properties remain poorly defined. Here, utilizing scRNA-seq data for 183,062 myeloid cells from 85 human tumors, we discover that nearly all glioma-associated myeloid cells express at least one of four immunomodulatory activity programs: Scavenger Immunosuppress...

Topics

Open a Topic to create a Post that cites this publication.

• Dexamethasone
• Immunomodulation
• Immunotherapy
• Interleukin-1beta
• Microglia
• Myeloid Cells
• Single-Cell Analysis
• Tumor Microenvironment

Identifiers and source

Literature Corpus work

908a22e1-c3d9-589a-96c8-f6764027d44f

DOI

10.1101/2023.10.24.563466