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Article

Single-cell characterization of macrophages in glioblastoma reveals MARCO as a mesenchymal pro-tumor marker.

Genome medicine - 19 May 2021

Chen Andrew X, Gartrell Robyn D, Zhao Junfei, Upadhyayula Pavan S, Zhao Wenting, Yuan Jinzhou, Minns Hanna E, Dovas Athanassios, Bruce Jeffrey N, Lasorella Anna, Iavarone Antonio, Canoll Peter, Sims Peter A, Rabadan Raul

Abstract excerpt

BACKGROUND: Macrophages are the most common infiltrating immune cells in gliomas and play a wide variety of pro-tumor and anti-tumor roles. However, the different subpopulations of macrophages and their effects on the tumor microenvironment remain poorly understood. METHODS: We combined new and previously published single-cell RNA-seq data from 98,015 single cells from a total of 66 gliomas to profile 19,331...

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Identifiers

PMID: 34011400
DOI: 10.1186/s13073-021-00906-x
PMCID: PMC8136167

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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