Distinct myeloid-derived suppressor cell populations in human glioblastoma.

doi:10.1126/science.abm5214

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Article

Distinct myeloid-derived suppressor cell populations in human glioblastoma.

Science (New York, N.Y.) - 17 Jan 2025

Jackson Christina, Cherry Christopher, Bom Sadhana, Dykema Arbor G, Wang Rulin, Thompson Elizabeth, Zhang Ming, Li Runzhe, Ji Zhicheng, Hou Wenpin, Zhan Wentao, Zhang Hao, Choi John, Vaghasia Ajay, Hansen Landon, Wang William, Bergsneider Brandon, Jones Kate M, Rodriguez Fausto, Weingart Jon, Lucas Calixto-Hope, Powell Jonathan, Elisseeff Jennifer, Yegnasubramanian Srinivasan, Lim Michael, Bettegowda Chetan, Ji Hongkai, Pardoll Drew

Abstract excerpt

The role of glioma-associated myeloid cells in tumor growth and immune evasion remains poorly understood. We performed single-cell RNA sequencing of immune and tumor cells from 33 gliomas, identifying two distinct myeloid-derived suppressor cell (MDSC) populations in isocitrate dehydrogenase-wild-type (IDT-WT) glioblastoma: an early progenitor MDSC (E-MDSC) population with up-regulation of metabolic and hypoxia...

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Identifiers

PMID: 39818911
DOI: 10.1126/science.abm5214
PMCID: PMC12836367

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