Genetics impact risk of Alzheimer's disease through mechanisms modulating structural brain morphology in late life.

doi:10.1136/jnnp-2023-332969

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Article

Genetics impact risk of Alzheimer's disease through mechanisms modulating structural brain morphology in late life.

Journal of neurology, neurosurgery, and psychiatry - 24 Mar 2025

Korologou-Linden Roxanna, Xu Bing, Coulthard Elizabeth, Walton Esther, Wearn Alfie, Hemani Gibran, White Tonya, Cecil Charlotte, Sharp Tamsin, Tiemeier Henning, Banaschewski Tobias, Bokde Arun, Desrivières Sylvane, Flor Herta, Grigis Antoine, Garavan Hugh, Gowland Penny, Heinz Andreas, Brühl Rüdiger, Martinot Jean-Luc, Paillère Martinot Marie-Laure, Artiges Eric, Nees Frauke, Orfanos Dimitri Papadopoulos, Paus Tomáš, Poustka Luise, Millenet Sabina, Fröhner Juliane H, Smolka Michael, Walter Henrik, Winterer Jeanne, Whelan Robert, Schumann Gunter, Howe Laura D, Ben-Shlomo Yoav, Davies Neil M, Anderson Emma Louise

Abstract excerpt

BACKGROUND: Alzheimer's disease (AD)-related neuropathological changes can occur decades before clinical symptoms. We aimed to investigate whether neurodevelopment and/or neurodegeneration affects the risk of AD, through reducing structural brain reserve and/or increasing brain atrophy, respectively. METHODS: We used bidirectional two-sample Mendelian randomisation to estimate the effects between genetic...

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Identifiers

PMID: 38663994
DOI: 10.1136/jnnp-2023-332969
PMCID: PMC7616849

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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