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Article

Causal relationships between neuroimaging phenotypes and the risk of early and late-onset alzheimer's disease.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology - 27 Dec 2025

Zhou Jinli, Chen Weiwei, Song Jinhui, Yu Danhua, Shi Chanhong, Luo Hangli, Huang Shaokang

Abstract excerpt

BACKGROUND & OBJECTIVES: Early-onset (EOAD) and late-onset Alzheimer's disease (LOAD) exhibit distinct genetic and neurobiological characteristics, yet their causal relationships with neuroimaging phenotypes remain unclear. This study aimed to investigate the potential causal effects of structural and functional brain alterations on AD subtypes using Mendelian Randomization (MR). METHODS: Two-sample MR analysis...

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PMID: 41454068
DOI: 10.1007/s10072-025-08667-w

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