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Article

APOE alleles are associated with sex-specific structural differences in brain regions affected in Alzheimer's disease and related dementia.

PLoS biology - 1 Dec 2022

Savignac Chloé, Villeneuve Sylvia, Badhwar AmanPreet, Saltoun Karin, Shafighi Kimia, Zajner Chris, Sharma Vaibhav, Gagliano Taliun Sarah A, Farhan Sali, Poirier Judes, Bzdok Danilo

Abstract excerpt

Alzheimer's disease is marked by intracellular tau aggregates in the medial temporal lobe (MTL) and extracellular amyloid aggregates in the default network (DN). Here, we examined codependent structural variations between the MTL's most vulnerable structure, the hippocampus (HC), and the DN at subregion resolution in individuals with Alzheimer's disease and related dementia (ADRD). By leveraging the power of the...

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Identifiers

PMID: 36512526
DOI: 10.1371/journal.pbio.3001863
PMCID: PMC9747055

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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