Article

Incorporating Multi-threshold Polygenic Risk in Hippocampal-based Normative Models Improves Cognitive Decline Prediction

2025-04-08

Abstract excerpt

<h4>ABSTRACT</h4> Predicting cognitive decline using MRI measures of brain volume is challenging. Normative models capture the evolution of biomarkers over time in a healthy group, quantifying an individual’s deviation from that norm. Here, we improve the precision of normative models for hippocampal volume, a key cognitive biomarker, by integrating multi-threshold polygenic scores (PGS) that capture genetic pred...

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Literature Corpus work: 617da452-9445-57ee-8b27-1e67a1b310be
DOI: 10.1101/2025.04.03.646991

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