Article
Vascular smooth muscle cell phenotypic plasticity: focus on chromatin remodelling.
Cardiovascular research - 15 Jul 2012
Spin Joshua M, Maegdefessel Lars, Tsao Philip S
Abstract excerpt
Differentiated vascular smooth muscle cells (SMCs) retain the capacity to modify their phenotype in response to inflammation or injury. This phenotypic switching is a crucial component of vascular disease, and is partly dependent on epigenetic regulation. An appreciation has been building in the literature for the essential role chromatin remodelling plays both in SMC lineage determination and in influencing...
Topics
- Animals
- Cell Differentiation
- Chromatin
- Chromatin Assembly and Disassembly
- Histones
- Humans
- Kruppel-Like Factor 4
- Myocytes, Smooth Muscle
- Phenotype