Article
Molecular control of vascular smooth muscle cell differentiation and phenotypic plasticity.
Novartis Foundation symposium - 1 Jan 2007
Owens Gary K
Abstract excerpt
Although the primary role of vascular smooth muscle cells (SMCs) is contraction, they exhibit extensive phenotypic diversity and plasticity during normal development, during repair of vascular injury, and in disease states including arteriosclerosis and tumour angiogenesis. Results of recent studies indicate that there are unique as well as common transcriptional regulatory mechanisms that control expression of...
Topics
- Cell Differentiation
- Disease
- Epigenesis, Genetic
- Humans
- Muscle, Smooth, Vascular
- Myocytes, Smooth Muscle
- Phenotype