Article

Pathways and signatures of mutagenesis at targeted DNA nicks

2021-01-08

Abstract excerpt

Nicks are the most frequent form of DNA damage and a potential source of mutagenesis in human cells. By deep sequencing, we have identified factors and pathways that promote and limit mutagenic repair at targeted nicks. BRCA2 inhibits all categories of mutational events at nicks, including indels, SNVs and HDR. DNA2 and RPA promote 5’ resection. Most insertions at nicks consist of a single C incorporated opposite...

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Literature Corpus work: ead18214-58f9-5b2e-a274-45d2533682c0
DOI: 10.1101/2021.01.08.425852

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