Article

NickSeq for genome-wide strand-specific identification of DNA single-strand break sites with single nucleotide resolution

2019-12-10

Abstract excerpt

<h4>ABSTRACT</h4> DNA single-strand breaks (SSBs), or ‘nicks’, are the most common form of DNA damage. Nicks occur at rates of tens of thousands per cell per day, and result from many sources including oxidative stress and endogenous enzyme activities. Accumulation of nicks, due to high rates of occurrence or defects in repair enzymes, has been implicated in multiple diseases. However, improved methods for nick a...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6a8c9ac9-402c-56bf-b7c3-c523c37d15bd
DOI: 10.1101/867937

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

NickSeq for genome-wide strand-specific identification of DNA single-strand break sites with single nucleotide resolutionDOI 10.1101/867937Read

Pathways and signatures of mutagenesis at targeted DNA nicksSemantic proximity Read

Enabling large-scale genome editing by reducing DNA nickingSemantic proximity Read

Nicking Loop™: An infinite amplification of single-stranded circular DNASemantic proximity Read

Prime editing with genuine Cas9 nickases minimizes unwanted indels.Semantic proximity Read

Highly sensitive mapping of <i>in vitro</i> type II topoisomerase DNA cleavage sites with SHAN-seqSemantic proximity Read

Mutational signature catalogue <i>(MUSIC)</i> of DNA double-strand break repairSemantic proximity Read

A mutational scar-based genome-wide map of DNA double-strand break repair.Semantic proximity Read

A comprehensive genetic catalog of human double-strand break repairSemantic proximity Read

Global detection of DNA repair outcomes induced by CRISPR-Cas9Semantic proximity Read

A novel approach reveals genomic landscapes of single-strand DNA breaks with nucleotide resolution in human cellsSemantic proximity Read

Detection of single-base mutation in RNA using T4 RNA ligase-based nick-joining or DNAzyme-based nick-generation.Semantic proximity Read

CRISPR-CAS9 D10A nickase target-specific fluorescent labeling of double strand DNA for whole genome mapping and structural variation analysis.Semantic proximity Read