Article

Spatial and temporal profiling of the complement system uncovered novel functions of the alternative complement pathway in brain development

2023-11-22

Abstract excerpt

<h4>Summary</h4> Mounting evidence implicated the classical complement pathway (CP) in normal brain development, and the pathogenesis of neuropsychiatric and neurodegenerative diseases. However the source and regulation of complement in the brain remain unclear. Using MERFISH, a spatial transcriptomic method with single-cell resolution, we established a developmental brain atlas of the complement system. We showe...

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Literature Corpus work: 4eb7befe-b033-5ea0-9251-c002f493e86d
DOI: 10.1101/2023.11.22.568325

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