Article

CDK4/6 inhibitors induce replication stress to cause long-term cell cycle withdrawal

2021-02-04

Abstract excerpt

<h4> A bstract </h4> CDK4/6 inhibitors arrest the cell cycle in G1-phase. They are approved to treat breast cancer and are also undergoing clinical trials against a range of other tumour types. To facilitate these efforts, it is important to understand why a cytostatic arrest in G1 causes long-lasting effects on tumour growth. Here we demonstrate that a prolonged G1-arrest following CDK4/6 inhibition downregula...

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Literature Corpus work: 9057c731-d312-5659-b34c-1b4f32920578
DOI: 10.1101/2021.02.03.428245

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