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Targeting DNA Replication Stress for Cancer Therapy

19 Aug 2016

Abstract excerpt

The human cellular genome is under constant stress from extrinsic and intrinsic factors, which can lead to DNA damage and defective replication. In normal cells, DNA damage response (DDR) mediated by various checkpoints will either activate the DNA repair system or induce cellular apoptosis/senescence, therefore maintaining overall genomic integrity. Cancer cells, however, due to constitutive growth signaling and...

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PMID: 27548226
DOI: 10.3390/genes7080051

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