Article

Oncogenic signals prime cancer cells for toxic cell growth during a G1 cell cycle arrest

2022-09-08

Abstract excerpt

<h4>SUMMARY</h4> A long-term goal in cancer research has been to inhibit the cell cycle in tumour cells without causing toxicity in proliferative healthy tissues. The best evidence that this is achievable is provided by CDK4/6 inhibitors, which arrest the cell cycle in G1, are well-tolerated in patients, and are effective in treating ER+/HER2-breast cancer. CDK4/6 inhibitors are effective because they arrest tumo...

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Literature Corpus work: 38ce8786-dcce-549f-9b50-2acc4cca05ec
DOI: 10.1101/2022.09.08.506962

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