Article

Cell enlargement causes mitotic errors and aneuploidy in cells that evade senescence after CDK4/6 inhibition

2025-07-02

Abstract excerpt

<h4> A bstract </h4> CDK4/6 inhibitors (CDK4/6i) arrest the cell cycle in G1 leading to cellular overgrowth and p53-dependent senescence. They are used to treat metastatic HR+/HER2-breast cancer, but resistance is common, and this has been associated with TP53 loss and senescence evasion. We show here that enlarged CDK4/6i-treated cells that evade senescence mis-segregate chromosomes due to defective chromosoma...

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Literature Corpus work: e888200a-a86a-5aaa-9ed0-c6edf71b02cb
DOI: 10.1101/2025.07.01.662622

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