Article

Palbociclib interferes with replication origin firing in a pRb independent manner

2022-09-22

Abstract excerpt

Over the last decade, CDK4/6 inhibitors (palbociclib, ribociclib and abemaciclib) have emerged as promising anticancer drugs. Numerous studies have demonstrated that CDK4/6 inhibitors efficiently block the pRb-E2F pathway and induce cell cycle arrest in pRb-proficient cells. Based on these studies, the inhibitors have been approved by the FDA for treatment of advanced hormonal receptor (HR) positive breast cancers...

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Literature Corpus work: cdf7e974-8e71-5531-9ff4-dcfcd297cac9
DOI: 10.1101/2022.09.21.508850

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