Article

S1P/S1PR1 signaling couples mitochondrial Ca²⁺-dependent cytoskeletal remodeling to IL-6/IL-33-driven macrophage polarization in breast cancer

2026-06-03

Abstract excerpt

<title>Abstract</title> <p>Sphingosine-1-phosphate (S1P) contributes to breast cancer progression; however, how it integrates metabolic reprogramming with remodeling of the tumor immune microenvironment (TIME)—a key driver of immune escape—remains unclear. Triple-negative breast cancer (TNBC), characterized by high metastatic potential and limited therapeutic options, urgently requires novel mechanistic targets f...

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Literature Corpus work: 148ff708-f830-5526-9e30-734212b39c2c
DOI: 10.21203/rs.3.rs-9578106/v1

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