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Article

Signaling modality within gp130 receptor enhances tissue regeneration

2022-01-05

Abstract excerpt

Adult mammals are incapable of multi-tissue regeneration and augmentation of this potential may drastically shift current therapeutic paradigms. Here, we found that a common co-receptor of IL-6 cytokines, glycoprotein 130 (gp130), serves as a major nexus integrating various context-specific signaling inputs to either promote regenerative outcomes or aggravate disease progression. Via genetic and pharmacological ex...

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Identifiers and source

Literature Corpus work
ff75ba9e-f677-57ad-a17e-4fb0c2abfe38
DOI
10.1101/2022.01.05.475124
Open publication

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Signaling modality within gp130 receptor enhances tissue regenerationDOI 10.1101/2022.01.05.475124
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