Article
Matriptase activation of Gq drives epithelial disruption and inflammation via RSK and DUOX.
eLife - 24 Jun 2021
Ma Jiajia, Scott Claire A, Ho Ying Na, Mahabaleshwar Harsha, Marsay Katherine S, Zhang Changqing, Teow Christopher Kj, Ng Ser Sue, Zhang Weibin, Tergaonkar Vinay, Partridge Lynda J, Roy Sudipto, Amaya Enrique, Carney Tom J
Abstract excerpt
Epithelial tissues are primed to respond to insults by activating epithelial cell motility and rapid inflammation. Such responses are also elicited upon overexpression of the membrane-bound protease, Matriptase, or mutation of its inhibitor, Hai1. Unrestricted Matriptase activity also predisposes to carcinoma. How Matriptase leads to these cellular outcomes is unknown. We demonstrate that zebrafish hai1a mutants...
Topics
- Animals
- Animals, Genetically Modified
- Calcium
- Calcium Signaling
- DNA
- Embryo, Nonmammalian
- Enzyme Activation
- GTP-Binding Protein alpha Subunits, Gq-G11
- Gene Expression Regulation, Enzymologic
- Hydrogen Peroxide
- Inflammation
- Mutation