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Novel determinant of antibiotic resistance: a clinically selected <i>Staphylococcus aureus clpP</i> mutant survives daptomycin treatment by reducing binding of the antibiotic and adapting a rod-shaped morphology

2023-03-08

Abstract excerpt

Daptomycin is a last-resort antibiotic used for treatment of infections caused by Gram-positive antibiotic-resistant bacteria such as methicillin-resistant Staphylococcus aureus (MRSA). Treatment failure is commonly linked to accumulation of point mutations, however, the contribution of single mutations to resistance and the mechanisms underlying resistance remain incompletely understood. Here we show that a sing...

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Literature Corpus work
8fef5d25-81aa-5acd-8ce7-ce57307933fd
DOI
10.1101/2023.03.06.531458
Open publication

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Novel determinant of antibiotic resistance: a clinically selected <i>Staphylococcus aureus clpP</i> mutant survives daptomycin treatment by reducing binding of the antibiotic and adapting a rod-shaped morphologyDOI 10.1101/2023.03.06.531458
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