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Article

Functional Characterisation of ClpP Mutations Conferring Resistance to Acyldepsipeptide Antibiotics in Firmicutes.

Chembiochem : a European journal of chemical biology - 16 Jul 2020

Malik Imran T, Pereira Rebeca, Vielberg Marie-Theres, Mayer Christian, Straetener Jan, Thomy Dhana, Famulla Kirsten, Castro Helena, Sass Peter, Groll Michael, Brötz-Oesterhelt Heike

Abstract excerpt

Acyldepsipeptide (ADEP) is an exploratory antibiotic with a novel mechanism of action. ClpP, the proteolytic core of the caseinolytic protease, is deregulated towards unrestrained proteolysis. Here, we report on the mechanism of ADEP resistance in Firmicutes. This bacterial phylum contains important pathogens that are relevant for potential ADEP therapy. For Staphylococcus aureus, Bacillus subtilis, enterococci...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32181548
DOI: 10.1002/cbic.201900787
PMCID: PMC7496096

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