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Article

dltA overexpression: A strain-independent keystone of daptomycin resistance in methicillin-resistant Staphylococcus aureus.

International journal of antimicrobial agents - 1 Jan 2014

Cafiso Viviana, Bertuccio Taschia, Purrello Simona, Campanile Floriana, Mammina Caterina, Sartor Assunta, Raglio Annibale, Stefani Stefania

Abstract excerpt

The mechanisms leading to reduced susceptibility to daptomycin (DAP) are multifactorial and have not been fully elucidated. We analysed, by sequencing and expression studies, the role of the major molecular targets (cell-envelope charge genes, dltA, mprF, cls2; cell-wall turnover and autolysis genes, sceD, atl) involved in the emergence of DAP resistance in three series of isogenic clinical methicillin-resistant...

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Identifiers

PMID: 24183798
DOI: 10.1016/j.ijantimicag.2013.10.001

Genes

DAP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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