Article

The ClpX chaperone controls the <i>Staphylococcus aureus</i> cell cycle but can be bypassed by β-lactam antibiotics

2018-05-03

Abstract excerpt

The worldwide spread of Staphylococcus aureus strains resistant to almost all β-lactam antibiotics is of major clinical concern. β-lactams interfere with cross-linking of the bacterial cell wall, but the killing mechanism of this important class of antibiotics is not fully understood. Here we show that sub-lethal doses of β-lactams stimulate the growth of S. aureus mutants lacking the widely conserved chaperone...

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Literature Corpus work: 159f072a-3b81-542a-932a-62796d573d71
DOI: 10.1101/313668

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