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Molecular Bases Determining Daptomycin Resistance-Mediated Resensitization to β-Lactams (Seesaw Effect) in Methicillin-Resistant Staphylococcus aureus.

Antimicrobial agents and chemotherapy - 1 Jan 2017

Renzoni Adriana, Kelley William L, Rosato Roberto R, Martinez Maria P, Roch Melanie, Fatouraei Maryam, Haeusser Daniel P, Margolin William, Fenn Samuel, Turner Robert D, Foster Simon J, Rosato Adriana E

Abstract excerpt

Antimicrobial resistance is recognized as one of the principal threats to public health worldwide, yet the problem is increasing. Infections caused by methicillin-resistant Staphylococcus aureus (MRSA) strains are among the most difficult to treat in clinical settings due to the resistance of MRSA to nearly all available antibiotics. The cyclic anionic lipopeptide antibiotic daptomycin (DAP) is the clinical...

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Identifiers

PMID: 27795377
DOI: 10.1128/AAC.01634-16
PMCID: PMC5192149

Genes

DAP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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