Article

Expression of <i>mecA</i> reduces the daptomycin susceptibility of <i>Staphylococcus aureus</i>

2025-02-11

Abstract excerpt

Staphylococcus aureus is a leading cause of bacteraemia and infections caused by methicillin-resistant strains (MRSA) are especially challenging to treat. MRSA strains are resistant to front-line beta-lactams due to PBP2a, a low-affinity penicillin-binding protein encoded by mecA . Daptomycin is used to treat MRSA infections but is not always effective and is associated with high rates of morbidity and mortality....

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Literature Corpus work: 2070eb8d-12e2-5e6f-895d-06ae6a744ae7
DOI: 10.1101/2025.02.10.637576

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