Article

A clinically annotated post-mortem approach to study multi-organ somatic mutational clonality in histologically healthy tissues

2022-03-01

Abstract excerpt

Recent research on histologically healthy human tissues identified omnipresent mutational microclones, driven by somatic mutations known to be responsible for carcinogenesis (e.g., in TP53 or NOTCH1 ). These new insights are fundamentally changing current tumour evolution models, with broad oncological implications. Most studies are based on surgical remnant tissues, which are not available for many organs and r...

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Literature Corpus work: 8fcf6c2e-de32-5328-8777-84562aed0d3d
DOI: 10.1101/2022.02.27.482170

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