Article
A clinically annotated post-mortem approach to study multi-organ somatic mutational clonality in normal tissues.
Scientific reports - 20 Jun 2022
Luijts Tom, Elliott Kerryn, Siaw Joachim Tetteh, Van de Velde Joris, Beyls Elien, Claeys Arne, Lammens Tim, Larsson Erik, Willaert Wouter, Vral Anne, Van den Eynden Jimmy
Abstract excerpt
Recent research on normal human tissues identified omnipresent clones of cells, driven by somatic mutations known to be responsible for carcinogenesis (e.g., in TP53 or NOTCH1). These new insights are fundamentally changing current tumor evolution models, with broad oncological implications. Most studies are based on surgical remnant tissues, which are not available for many organs and rarely in a pan-organ...
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