Article
Selection of Oncogenic Mutant Clones in Normal Human Skin Varies with Body Site.
Cancer discovery - 1 Feb 2021
Fowler Joanna C, King Charlotte, Bryant Christopher, Hall Michael W J, Sood Roshan, Ong Swee Hoe, Earp Eleanor, Fernandez-Antoran David, Koeppel Jonas, Dentro Stefan C, Shorthouse David, Durrani Amer, Fife Kate, Rytina Edward, Milne Doreen, Roshan Amit, Mahububani Krishnaa, Saeb-Parsy Kourosh, Hall Benjamin A, Gerstung Moritz, Jones Philip H
Abstract excerpt
Skin cancer risk varies substantially across the body, yet how this relates to the mutations found in normal skin is unknown. Here we mapped mutant clones in skin from high- and low-risk sites. The density of mutations varied by location. The prevalence of NOTCH1 and FAT1 mutations in forearm, trunk, and leg skin was similar to that in keratinocyte cancers. Most mutations were caused by ultraviolet light, but...
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