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Article

Clonal Evolution in Healthy and Premalignant Tissues: Implications for Early Cancer Interception Strategies.

Cancer prevention research (Philadelphia, Pa.) - 5 Jul 2023

Rane Jayant K, Frankell Alexander M, Weeden Clare E, Swanton Charles

Abstract excerpt

Histologically normal human tissues accumulate significant mutational burden with age. The extent and spectra of mutagenesis are comparable both in rapidly proliferating and post-mitotic tissues and in stem cells compared with their differentiated progeny. Some of these mutations provide increased fitness, giving rise to clones which, at times, can replace the entire surface area of tissues. Compared with cancer,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36930945
DOI: 10.1158/1940-6207.CAPR-22-0469
PMCID: PMC7614725

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