Article

Large-Scale Genome-Wide Optimization and Prediction of the Cre Recombinase System for Precise Genome Manipulation in Mice

2024-07-03

Abstract excerpt

<title>Abstract</title> <p>The Cre-Lox recombination system is a powerful tool in mouse genetics, offering spatial-temporal control over gene expression and facilitating the large-scale generation of conditional knockout mice. Its versatility also extends to other research models, such as rats, pigs, and zebrafish. However, the Cre-Lox technology presents a set of challenges that includes high costs, a time-inten...

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Literature Corpus work: 8fcb0c78-5e44-53aa-8252-c69f02c467b5
DOI: 10.21203/rs.3.rs-4595968/v1

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