Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Overview of gene targeting by homologous recombination.

Current protocols in neuroscience - 1 Jul 2007

Mortensen Richard

Abstract excerpt

The analysis of mutant organisms and cell lines is important in determining the function of specific proteins. Recent technological advances in gene targeting by homologous recombination in mammalian systems enable the production of mutants in any desired gene, and can be used to produce mutant mouse strains and mutant cell lines. The yeast Flp/FRT recombinase system and bacteriophage recombinases such as Cre and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Mammals
Share to Molecular Biology
Share to Mutagenesis

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mutation

Share to Recombination, Genetic

Source

Identifiers

PMID: 18428657
DOI: 10.1002/0471142301.ns0429s40

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Overview of gene targeting by homologous recombination.PMID 18428657Read ↗

Gene targeting in mice: a review.Semantic proximity Read ↗

A highly efficient recombineering-based method for generating conditional knockout mutations.Semantic proximity Read ↗

Production of a heterozygous mutant cell line by homologous recombination (single knockout).Semantic proximity Read ↗

Production of a heterozygous mutant cell line by homologous recombination (single knockout).Semantic proximity Read ↗

Overview of gene targeting by homologous recombination.Semantic proximity Read ↗

Mammalian genome targeting using site-specific recombinases.Semantic proximity Read ↗

Gene targeting in the mouse.Semantic proximity Read ↗

Knock-in approaches.Semantic proximity Read ↗

Ten years of gene targeting: targeted mouse mutants, from vector design to phenotype analysis.Semantic proximity Read ↗

Production of a heterozygous mutant cell line by homologous recombination (single knockout).Semantic proximity Read ↗

Generation of knockout alleles by RFLP based BAC targeting of polymorphic embryonic stem cells.Semantic proximity Read ↗

Mutant loxP vectors for selectable marker recycle and conditional knock-outs.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.