Article

Large-Scale Genome-Wide Optimization and Prediction of the Cre Recombinase System for Precise Genome Manipulation in Mice

2024-06-17

Abstract excerpt

The Cre-Lox recombination system is a powerful tool in mouse genetics, offering spatial-temporal control over gene expression and facilitating the large-scale generation of conditional knockout mice. Its versatility also extends to other research models, such as rats, pigs, and zebrafish. However, the Cre-Lox technology presents a set of challenges that includes high costs, a time-intensive process, and the occurr...

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Literature Corpus work: a3d45919-f7cd-5bc2-9a8c-ed0d93ab889e
DOI: 10.1101/2024.06.14.599022

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