Article

Divergent effects of C4a, C4a <sup>desArg</sup> , and thrombin on platelet aggregation and phosphorylation of ERK and Akt in human endothelial cells

2024-03-15

Abstract excerpt

Prior studies have established C4a as an untethered ligand for protease-activated receptors (PAR)1 and PAR4, which can increase ERK phosphorylation and [Ca 2+ ] i influx in human endothelial cells (ECs). C4a desArg is a stable metabolite produced from C4a through cleavage of an arginine at the carboxyl terminus by plasma carboxypeptidases B/N. PAR1 and PAR4 are typical receptors for thrombin and transduce cellu...

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Literature Corpus work: 8fc77a70-64a0-590c-9b7d-63588275cff1
DOI: 10.1101/2024.03.13.584877

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