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Article

Protease‐activated receptor 4: from structure to function and back again

5 Feb 2016

Abstract excerpt

Protease-activated receptors are a family of four GPCRs (PAR1-PAR4) with a number of unique attributes. Nearly two and a half decades after the discovery of the first PAR, an antagonist targeting this receptor has been approved for human use. The first-in-class PAR1 antagonist, vorapaxar, was approved for use in the USA in 2014 for the prevention of thrombotic cardiovascular events in patients with a history of...

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PMID: 26844674
DOI: 10.1111/bph.13455

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