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Article

Endothelial protease-activated receptor 4: impotent or important?

28 Jan 2025

Abstract excerpt

The protease thrombin, which increases its levels with various pathologies, can signal through the G protein-coupled receptors protease-activated receptors 1 and 4 (PAR1/PAR4). PAR1 is a high-affinity receptor for thrombin, whereas PAR4 is a low-affinity receptor. Finding functions for PAR4 in endothelial cells (ECs) has been an elusive goal over the last two decades. Several studies have demonstrated a lack of...

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PMID: 39935714
DOI: 10.3389/fcvm.2025.1541879

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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