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Article

Protease-activated receptor 3 is a second thrombin receptor in humans.

Nature - 3 Apr 1997

Ishihara H, Connolly A J, Zeng D, Kahn M L, Zheng Y W, Timmons C, Tram T, Coughlin S R

Abstract excerpt

Thrombin is a coagulation protease that activates platelets, leukocytes, endothelial and mesenchymal cells at sites of vascular injury, acting partly through an unusual proteolytically activated G-protein-coupled receptor. Knockout of the gene encoding this receptor provided definitive evidence f...

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PMID: 9087410
DOI: 10.1038/386502a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-9087410-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Protease-activated receptor 3 is a second thrombin receptor in humans.PMID 9087410Read ↗

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A Mouse Model of the Protease Activated Receptor 4 (PAR4) Pro310Leu Variant has Reduced Platelet ReactivitySemantic proximity Read ↗

The Human Proteinase-activated Receptor-3 (PAR-3) GeneSemantic proximity Read ↗

Cloning and characterization of human protease-activated receptor 4.Semantic proximity Read ↗

A role for thrombin receptor signaling in endothelial cells during embryonic development.Semantic proximity Read ↗

Human PAR1 expressed on mouse platelets contributes to hemostasis and arterial occlusionSemantic proximity Read ↗

Lack of canonical PAR4 activation is associated with reduced arterial and venous thrombosis in miceSemantic proximity Read ↗

Impaired hemostasis and protection against thrombosis in protease-activated receptor 4-deficient mice is due to lack of thrombin signaling in platelets.Semantic proximity Read ↗

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