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Article

The endothelial cell protein C receptor: its role in thrombosis.

Thrombosis research - 1 Nov 2011

Navarro Silvia, Bonet Elena, Estellés Amparo, Montes Ramón, Hermida José, Martos Laura, España Francisco, Medina Pilar

Abstract excerpt

The protein C anticoagulant pathway plays a crucial role as a regulator of the blood clotting cascade. Protein C is activated on the vascular endothelial cell membrane by the thrombin-thrombomodulin complex. The endothelial protein C receptor binds protein C and further enhances protein C activation. Once formed, activated protein C down-regulates thrombin formation by inactivating factors Va and VIIIa and exerts...

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PMID: 21903242
DOI: 10.1016/j.thromres.2011.08.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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