Article
Thrombin-Mediated Direct Activation of Proteinase-Activated Receptor-2: Another Target for Thrombin Signaling.
Molecular pharmacology - 1 May 2016
Mihara Koichiro, Ramachandran Rithwik, Saifeddine Mahmoud, Hansen Kristina K, Renaux Bernard, Polley Danny, Gibson Stacy, Vanderboor Christina, Hollenberg Morley D
Abstract excerpt
Thrombin is known to signal to cells by cleaving/activating a G-protein-coupled family of proteinase-activated receptors (PARs). The signaling mechanism involves the proteolytic unmasking of an N-terminal receptor sequence that acts as a tethered receptor-activating ligand. To date, the recognized targets of thrombin cleavage and activation for signaling are PAR1 and PAR4, in which thrombin cleaves at a conserved...
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