Article
Activated protein C β-glycoform promotes enhanced noncanonical PAR1 proteolysis and superior resistance to ischemic injury.
Blood - 13 Aug 2015
Gleeson Eimear M, Dichiara María G, Salicio Agustina, Quinn Louise M, Drakeford Clive, Russell Shane E, Walsh Patrick T, Orbe Josune, Hermida José, Smith Owen P, O'Donnell James S, Montes Ramón, Preston Roger J S
Abstract excerpt
Activated protein C (APC) is an anticoagulant protease that initiates cell signaling via protease-activated receptor 1 (PAR1) to regulate vascular integrity and inflammatory response. In this study, a recombinant APC variant (APC(N329Q)) mimicking the naturally occurring APC-β plasma glycoform was found to exhibit superior PAR1 proteolysis at a cleavage site that selectively mediates cytoprotective signaling....
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