Article

Protease-Activated Receptor 1 as an Endogenous Model of Peptidergic Gαq-Gα12-Biased G Protein Signaling

2026-03-04

Abstract excerpt

G protein-coupled receptors (GPCRs) are the most widely targeted class of signaling proteins, comprising ~30% of FDA-approved drugs. Their therapeutic potential arises from their ability to translate diverse extracellular cues into intracellular signals via G proteins, arrestins, and other effectors. This signaling versatility creates opportunities for functional selectivity, where ligands preferentially engage pa...

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Literature Corpus work: b33ac847-5712-54e2-95fd-9aefcec96b5e
DOI: 10.64898/2026.03.03.709348

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