Article

Statistical Assessment of Biomarker Replicability using MAJAR Method

2022-12-09

Abstract excerpt

In the era of precision medicine, many biomarkers have been discovered to be associated with drug efficacy and safety responses, which can be used for patient stratification and drug response prediction. Due to small sample size and limited power of randomized clinical studies, meta-analysis is usually conducted to aggregate all available studies to maximize the power for identifying prognostic and predictive biom...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8fc51594-85bc-5abb-9750-8d62d4b84013
DOI: 10.1101/2022.12.08.22283210

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Statistical Assessment of Biomarker Replicability using MAJAR MethodDOI 10.1101/2022.12.08.22283210Read

Statistical assessment of biomarker replicability using MAJAR method.Semantic proximity Read

Model-based assessment of replicability for genome-wide association meta-analysis.Semantic proximity Read

SNP characteristics predict replication success in association studies.Semantic proximity Read

Confident identification of subgroups from SNP testing in RCTs with binary outcomes.Semantic proximity Read

A powerful approach to identify replicable variants in genome-wide association studies.Semantic proximity Read

A simple approximation to bias in the genetic effect estimates when multiple disease states share a clinical diagnosisSemantic proximity Read

repfdr: a tool for replicability analysis for genome-wide association studies.Semantic proximity Read

Effectiveness of strategies to increase the validity of findings from association studies: size vs. replication.Semantic proximity Read

Replicability and Prediction: Lessons and Challenges from GWAS.Semantic proximity Read

MAX precision test of the Genome-wide association study under two-stage designSemantic proximity Read

In Pursuit of Greater Reproducibility and Credibility of Early Clinical Biomarker ResearchSemantic proximity Read

CARLIS: covariate-assisted replicability analysis for genome-wide association studies via triplet hidden Markov models.Semantic proximity Read