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Article

Model-based assessment of replicability for genome-wide association meta-analysis.

Nature communications - 30 Mar 2021

McGuire Daniel, Jiang Yu, Liu Mengzhen, Weissenkampen J Dylan, Eckert Scott, Yang Lina, Chen Fang, Berg Arthur, Vrieze Scott, Jiang Bibo, Li Qunhua, Liu Dajiang J

Abstract excerpt

Genome-wide association meta-analysis (GWAMA) is an effective approach to enlarge sample sizes and empower the discovery of novel associations between genotype and phenotype. Independent replication has been used as a gold-standard for validating genetic associations. However, as current GWAMA often seeks to aggregate all available datasets, it becomes impossible to find a large enough independent dataset to...

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Identifiers

PMID: 33785739
DOI: 10.1038/s41467-021-21226-z
PMCID: PMC8009871

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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