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Statistical assessment of biomarker replicability using MAJAR method.

Statistical methods in medical research - 1 Oct 2023

Xie Yuhan, Zhai Song, Jiang Wei, Zhao Hongyu, Mehrotra Devan V, Shen Judong

Abstract excerpt

In the era of precision medicine, many biomarkers have been discovered to be associated with drug efficacy and safety responses, which can be used for patient stratification and drug response prediction. Due to the small sample size and limited power of randomized clinical studies, meta-analysis is usually conducted to aggregate all available studies to maximize the power for identifying prognostic and predictive...

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PMID: 37519295
DOI: 10.1177/09622802231188519

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