Article
Replicability and Prediction: Lessons and Challenges from GWAS.
Trends in genetics : TIG - 1 Jul 2018
Marigorta Urko M, Rodríguez Juan Antonio, Gibson Greg, Navarro Arcadi
Abstract excerpt
Since the publication of the Wellcome Trust Case Control Consortium (WTCCC) landmark study a decade ago, genome-wide association studies (GWAS) have led to the discovery of thousands of risk variants involved in disease etiology. This success story has two angles that are often overlooked. First, GWAS findings are highly replicable. This is an unprecedented phenomenon in complex trait genetics, and indeed in many...
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