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Article

A powerful approach to identify replicable variants in genome-wide association studies.

American journal of human genetics - 2 May 2024

Li Yan, Lei Haochen, Wen Xiaoquan, Cao Hongyuan

Abstract excerpt

Replicability is the cornerstone of modern scientific research. Reliable identifications of genotype-phenotype associations that are significant in multiple genome-wide association studies (GWASs) provide stronger evidence for the findings. Current replicability analysis relies on the independence assumption among single-nucleotide polymorphisms (SNPs) and ignores the linkage disequilibrium (LD) structure. We...

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Identifiers

PMID: 38701746
DOI: 10.1016/j.ajhg.2024.04.004
PMCID: PMC11080610

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