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Article

CARLIS: covariate-assisted replicability analysis for genome-wide association studies via triplet hidden Markov models.

Genetics - 4 Feb 2026

Li Yan, Ma Han, Li Yanmei, Zhang Xin

Abstract excerpt

Replicability analysis is a cornerstone for identifying genuine genetic associations in genome-wide association studies (GWAS), yet existing methods are constrained by their failure to account for linkage disequilibrium (LD) structure among single nucleotide polymorphisms (SNPs) or underuse of auxiliary information, limiting their reliability and statistical power. We develop CARLIS, a comprehensive...

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PMID: 41354059
DOI: 10.1093/genetics/iyaf261

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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