Article

Antigen experience history directs distinct functional states of CD8+ CAR T cells during the anti-leukemia response

2023-12-21

Abstract excerpt

<title>Abstract</title> Chimeric antigen receptor T cells are an effective therapy for B-lineage malignancies. However, many patients relapse and this therapeutic has yet to show strong efficacy in other hematologic or solid tumors. One opportunity for improvement lies in the ability to generate T cells with desirable functional characteristics. Here, we dissect the biology of CD8+ CAR T cells (CAR8) by contro...

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Literature Corpus work: 8faede13-83e4-5a03-9312-6e472c871b2b
DOI: 10.21203/rs.3.rs-3712137/v1

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